Neils Bohr once said: "It is wrong to think that the task of physics is to find out how nature is. Physics concerns what we can say about nature."
The founding father of Computer Science, Alan Turing also came up with a test for artificial intelligence based on observations alone. Scott's post about Turing's philosophy about machines and morals is worth a read. Also (after reminded by Scott's post) according to Aumman's theorem we have to behave based on observable priors to be considered "rational".
Einstein effectively was unproductive after generalizing his theory of relativity "for invariance results among accelerating frames" because of his trouble accepting the uncertainities underlying Nature's laws. I intend to add a full post about uncertainties but for this post I would like to say that all these statements suggest us to use concrete evidence in all walks of life instead getting drained by intangible correlations woven by emotions.